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Interspecies transmission and evolution of the emerging coronaviruses: perspectives from bat physiology and protein

Baicheng HUANG, Kegong TIAN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 218-226 doi: 10.15302/J-FASE-2020324

Abstract: The relationship of spatial structural characteristics of the spike protein, a protein that is critical

Keywords： bat     coronavirus     evolution     host receptor     spike protein     transmission    

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Molecular aspects of MERS-CoV

Ali A. Rabaan, Ali M. Bazzi, Shamsah H. Al-Ahmed, Jaffar A. Al-Tawfiq

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 365-377 doi: 10.1007/s11684-017-0521-z

Abstract: Evolutionary changes in the virus, particularly in the viral spike protein which mediates virus-hostSynthetic peptides and candidate vaccines based on regions of the spike protein have shown promise inGLS-5300, a prophylactic DNA-plasmid vaccine encoding S protein, is the first MERS-CoV vaccine to be

Keywords： MERS-CoV     Saudi Arabia     spike protein     transmission     evolution     vaccine    

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Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins Review

Yan-Hua Li, Chen-Yu Hu, Nan-Ping Wu, Hang-Ping Yao, Lan-Juan Li

Engineering 2019, Volume 5, Issue 5,   Pages 940-947 doi: 10.1016/j.eng.2018.11.035

Abstract:

Middle East respiratory syndrome (MERS) is a viral respiratory disease caused by a de novo coronavirus—Middle East respiratory syndrome coronavirus (MERS-CoV)—that is associated with high mortality. However, the mechanism by which MERS-CoV infects humans remains unclear. To date, there is no effective vaccine or antibody for human immunity and treatment, other than the safety and tolerability of the fully human polyclonal Immunoglobulin G (IgG) antibody (SAB-301) as a putative therapeutic agent specific for MERS. Although rapid diagnostic and public health measures are currently being implemented, new cases of MERS-CoV infection are still being reported. Therefore, various effective measures should be taken to prevent the serious impact of similar epidemics in the future. Further investigation of the epidemiology and pathogenesis of the virus, as well as the development of effective therapeutic and prophylactic anti-MERS-CoV infections, is necessary. For this purpose, detailed information on MERS-CoV proteins is needed. In this review, we describe the major structural and nonstructural proteins of MERS-CoV and summarize different potential strategies for limiting the outbreak of MERS-CoV. The combination
of computational biology and virology can accelerate the advanced design and development of effective peptide therapeutics against MERS-CoV. In summary, this review provides important information about the progress of the elimination of MERS, from prevention to treatment.

Keywords： MERS-CoV     Spike protein     Structural protein     Accessory protein     Nonstructural protein    

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Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Article

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Engineering 2021, Volume 7, Issue 10,   Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014

Abstract: this mass spectrometry (MS)-based study, we reveal that out of 21 possible glycosites in the HCoV-19 spikeprotein (S protein), 20 are completely occupied by N-glycans, predominantly of the oligomannoseHowever, glycosylation did not directly contribute to the binding affinity between HCoV-19 S proteinRefined structural models of HCoV-19 S protein and hACE2 were built by adding N-glycan and PTMsThe PTM and glycan maps of HCoV-19 S protein and hACE2 provide additional structural details for studying

Keywords： N-glycosylation     COVID-19     Spike protein     hACE2     Structure    

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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Wheat gluten protein and its impacts on wheat processing quality

Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3,   Pages 279-287 doi: 10.15302/J-FASE-2019267

Abstract: Wheat grain protein is divided into gluten and non-gluten fractions and the wheat processing qualityBased on the SDS-extractability, grain protein is divided into SDS-unextractable polymeric protein (UPP) and SDS-extractable polymeric protein.

Keywords： wheat gluten     consensus motifs     disulfide bonds     SDS-unextractable polymeric protein     glutenins     gliadins     processing quality     storage protein    

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Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 8,   Pages 1131-1139 doi: 10.1007/s11705-023-2321-0

Abstract: modification of silk fabric by impregnation with riboflavin sodium phosphate was proposed, such that protein

Keywords： biomass     riboflavin sodium phosphate     silk protein     multifunctional modification     flame retardant    

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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract:

Antithrombin and protein C are two crucial members in the anticoagulant system and play importantCoagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased proteinThis study demonstrates that the combination of antithrombin deficiency and decreased protein C activity

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

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Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 30-35 doi: 10.1007/s11684-009-0005-x

Abstract: The role of high sensitivity C-reactive protein (hsCRP) in predicting prognosis after stroke in the Asian

Keywords： C-reactive protein     inflammation     stroke    

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Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 919-931 doi: 10.1007/s11684-021-0918-6

Abstract: This study describes a strategy to prevent PE by reducing MP release using the recombinant protein, diannexin

Keywords： preeclampsia     recombinant protein diannexin     microparticle     NLRP3 inflammasome     phosphatidylserin    

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Investigation of hydrolysis conditions and properties on protein hydrolysates from flatfish skin

Hua ZHANG, Hongji ZHU, Shipeng WANG, Weihua WANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 3,   Pages 303-311 doi: 10.1007/s11705-013-1341-6

Abstract: based on Box-Behnken design, was used to optimize the enzymatic hydrolysis conditions of flatfish skin protein

Keywords： flatfish skin     protein hydrolysates     metal chelating activity     reducing power    

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Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 26-29 doi: 10.1007/s11684-009-0008-7

Abstract: clone formation assay, and western blot was applied to detect the expressions of Ku80, DNA-PKcs and ATM proteinThe correlativity of protein expression with SF2 value was analyzed by Pearson linear correlation analysisWe found that the expression of same protein in different cell lines and the expression of three proteinsThese findings suggest that the expression level of DNA-PKcs protein can be an indicator for predicting

Keywords： Ku80     DNA-PK(cs)-binding protein     human     ataxia telangiectasia mutated protein     tumor cell lines     radiosensitivity    

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Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 8-12 doi: 10.1007/s11684-009-0017-6

Abstract: Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells.is suggested to be involved in neurofibrillary tangle (NFT) formation, disturbed amyloid precursor protein

Keywords： protein phosphatase 2A     Alzheimer’s disease     holoenzyme composition     protein phosphatase 2A inhibitors     Leu309    

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Molecular mechanisms of leukemia-associated protein degradation

Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 363-370 doi: 10.1007/s11684-010-0210-7

Abstract: as retinoic acid receptor-alpha (RARα), acute myeloid leukemia 1 (AML1), CAAT/enhancer-binding proteinUbiquitin-mediated protein degradation represents a critical mechanism in regulating the cellular levelsThus, targeting protein degradation has been emerging as an important strategy to conquer malignant diseasesIn this review, we will summarize the recent advances in the understanding of the roles of protein degradation

Keywords： protein degradation     leukemia     chemical biology     transcription factors     oncoprotein    

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Title Author Date Type Operation

Interspecies transmission and evolution of the emerging coronaviruses: perspectives from bat physiology and protein

Baicheng HUANG, Kegong TIAN

Journal Article

Molecular aspects of MERS-CoV

Ali A. Rabaan, Ali M. Bazzi, Shamsah H. Al-Ahmed, Jaffar A. Al-Tawfiq

Journal Article

Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins

Yan-Hua Li, Chen-Yu Hu, Nan-Ping Wu, Hang-Ping Yao, Lan-Juan Li

Journal Article

Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Wheat gluten protein and its impacts on wheat processing quality

Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM

Journal Article

Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin

Journal Article

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article

Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Journal Article

Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

Journal Article

Investigation of hydrolysis conditions and properties on protein hydrolysates from flatfish skin

Hua ZHANG, Hongji ZHU, Shipeng WANG, Weihua WANG

Journal Article

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Journal Article

Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Journal Article

Molecular mechanisms of leukemia-associated protein degradation

Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,

Journal Article